neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model
نویسندگان
چکیده
parkinson disease (pd) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. due to the neuroprotective property of the nigella sativa bioactive compound thymoquinone (tq), this study was undertaken to evaluate whether tq could improve behavioral and cellular abnormalities and markers of oxidative stress in an experimental model of early pd in rat. unilateral intrastriatal 6-hydroxydopamine (6-ohda)-lesioned rats were daily pretreated p.o. with tq at doses of 5 and/or 10 mg/kg three times at an interval of 24 h. after 1 week, apomorphine caused contralateral rotations, a reduction in the number of neurons on the left side of the substantia nigra pars compacta (snc) was observed, malondialdehyde (mda) and nitrite level in midbrain homogenate increased and activity of superoxide dismutase (sod) reduced in the 6-ohda lesion group. tq pretreatment significantly improved turning behavior, prevented loss of snc neurons,and lowered level of mda. these results suggest that tq could afford neuroprotection against 6-ohda neurotoxicity that is partly due to the attenuation of lipid peroxidation and this may provide benefits, along with other therapies, in neurodegenerative disorders including pd.
منابع مشابه
Neuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
متن کاملNeuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
متن کاملNeuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
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Background and Objective: A huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in Parkinson’s disease (PD). Polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...
متن کاملMelissa officinalis aqueous extract ameliorates 6-hydroxydopamine-induced neurotoxicity in hemi-parkinsonian rat
ABSTRACT Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disorder with massive loss of dopaminergic neurons in the substantia nigra pars compacta. L-Dihydroxyphenylalanine (L-DOPA) substitution is still the gold standard therapy for PD. However, there has been little information available on neuroprotective and regenerative therapies for PD. Due to the neu...
متن کاملprotective effect of carvacrol in 6-hydroxydopamine hemi-parkinsonian rat model
background and objective: a huge amount of investigational evidence support a role for oxidative stress as an intermediary of nerve cell dysfunction in parkinson’s disease (pd). polyphenols such as carvacrol have been indicated to prevent neuronal deterioration caused by increased oxidative load, thus, this study evaluated whether carvacrol administration would attenuate behavioral abnormalitie...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۳، شماره ۱، صفحات ۲۲۷-۲۳۴
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